Table 3.
Differential candidate gene expressions in patients with IgA nephropathy compared with healthy controls from an open database
| Candidate Gene | Samples | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Renal Biopsies | Whole Blood: Experiment E-GEOD-14795 | ||||||||
| Experiment E-GEOD-37460 | Experiment E-GEOD-35489 | ||||||||
| IgAN (n=27) | Controls (n=27) | P Value | IgAN (n=25) | Controls (n=6) | P Value | IgAN (n=12) | Controls (n=8) | P Value | |
| CFH | 9.41±0.94 | 8.95±0.64 | 4.09×10−2a | 5.72±0.32 | 5.51±0.14 | 0.14 | 96.90±56.10 | 88.11±61.04 | 0.74 |
| HLA-DRA | 11.59±0.33 | 10.89±0.54 | 6.56×10−7a,b | 9.42±0.76 | 8.62±0.27 | 2.56×10−4a,b | 8576.43±2251.01 | 8638.24±2355.87 | 0.95 |
| HLA-DRB1 | 13.10±0.26 | 12.52±0.51 | 4.22×10−6a,b | 11.31±0.65 | 10.43±0.28 | 5.58×10−5a,b | 16661.58±5086.23 | 15779.10±3730.21 | 0.68 |
| PXK | – | – | – | – | – | – | – | – | – |
| BLK | 4.91±0.25 | 4.82±0.17 | 0.14 | 4.48±0.13 | 4.44±0.13 | 0.53 | 372.31±148.09 | 245.60±104.07 | 3.75×10−2a |
| UBE2L3 | 9.58±0.18 | 9.66±0.29 | 0.21 | 7.94±0.13 | 7.75±0.16 | 3.24×10−3a | 492.78±94.12 | 362.57±132.65 | 1.90×10−2a |
Data are the means±SD. IgAN, IgA nephropathy.
a
P<0.05.
b
P values remained significant after multiple correction using Benjamini and Hochberg false-discovery rate methods.