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Joint effects of newly identified loci stratified by the number of protective alleles
| Protective Alleles (n) | Frequency in Cases/Controls (%/%) | Odds Ratio (95% CI) | P Value |
|---|---|---|---|
| ≤2 | 5.4/1.9 | 1.00 (Reference) | |
| 3 | 13.5/10.3 | 0.46 (0.25 to 0.83) | 9.11×10−3 |
| 4 | 25.7/19.5 | 0.46 (0.26 to 0.82) | 6.68×10−3 |
| 5 | 26.3/25.4 | 0.36 (0.21 to 0.64) | 2.73×10−4 |
| 6 | 19.0/21.4 | 0.31 (0.18 to 0.55) | 3.06×10−5 |
| 7 | 6.4/13.3 | 0.17 (0.09 to 0.31) | 1.44×10−9 |
| ≥8 | 3.7/8.0 | 0.16 (0.08 to 0.31) | 8.77×10−9 |
