Table 4.
Cox regression analysis between all-cause and cardiovascular mortality and glucose disposal rate in 446 nondiabetic men with CKD
| Cox Regression Models | M (milligrams per kilogram per minute) | Hazard Ratio (95% CI) | |||
|---|---|---|---|---|---|
| Crude Model | Adjusted Model 1 | Adjusted Model 2 | Adjusted Model 3 | ||
| All-cause mortality | |||||
| Continuous model | 1-mg/kg per minute increment | 0.96 (0.89 to 1.03) | 0.94 (0.85 to 1.04) | 0.95 (0.86 to 1.05) | 0.96 (0.87 to 1.06) |
| Multicategory model | |||||
| Quartile 1 | ≤4.1 | Reference | Reference | Reference | Reference |
| Quartile 2 | 4.1–5.3 | 0.73 (0.47 to 1.15) | 0.74 (0.44 to 1.23) | 0.72 (0.42 to 1.22) | 0.76 (0.45 to 1.29) |
| Quartile 3 | 5.3–6.7 | 0.79 (0.51 to 1.24) | 0.75 (0.43 to 1.28) | 0.82 (0.47 to 1.44) | 0.88 (0.50 to 1.53) |
| Quartile 4 | >6.7 | 0.77 (0.49 to 1.21) | 0.68 (0.38 to 1.23) | 0.71 (0.38 to 1.30) | 0.78 (0.42 to 1.44) |
| P for trend | 0.53 | 0.58 | 0.60 | 0.75 | |
| Threshold model | |||||
| Quartile 1 | ≤4.1 | Reference | Reference | Reference | Reference |
| Quartile 2–4 | >4.1 | 0.76 (0.53 to 1.10) | 0.73 (0.46 to 1.15) | 0.77 (0.48 to 1.23) | 0.80 (0.50 to 1.28) |
| Cardiovascular mortality | |||||
| Continuous model | 1-mg/kg per minute increment | 0.90 (0.81 to 1.01) | 0.90 (0.78 to 1.04) | 0.95 (0.83 to 1.09) | 0.96 (0.83 to 1.10) |
| Multicategory model | |||||
| Quartile 1 | ≤4.1 | Reference | Reference | Reference | Reference |
| Quartile 2 | 4.1–5.3 | 0.63 (0.34 to 1.14) | 0.67 (0.34 to 1.31) | 0.73 (0.37 to 1.46) | 0.74 (0.37 to 1.48) |
| Quartile 3 | 5.3–6.7 | 0.49 (0.25 to 0.94) | 0.45 (0.20 to 0.99) | 0.60 (0.27 to 1.34) | 0.61 (0.27 to 1.36) |
| Quartile 4 | >6.7 | 0.53 (0.28 to 1.01) | 0.47 (0.20 to 1.08) | 0.64 (0.27 to 1.50) | 0.66 (0.28 to 1.55) |
| P for trend | 0.10 | 0.20 | 0.62 | 0.65 | |
| Threshold model | |||||
| Quartile 1 | ≤4.1 | Reference | Reference | Reference | Reference |
| Quartile 2–4 | >4.1 | 0.55 (0.34 to 0.89) | 0.56 (0.30 to 1.04) | 0.67 (0.36 to 1.26) | 0.68 (0.36 to 1.29) |
Covariance in adjusted model 1 includes age, body mass index, smoking status, and physical activity. Covariance in adjusted model 2 includes age, body mass index, smoking status, physical activity, cardiovascular disease, and UAER. Covariance in adjusted model 3 includes age, body mass index, smoking status, physical activity, cardiovascular disease, UAER, and eGFR. M, glucose disposal rate.