Table 7.

Inclusion of biomarkers significantly improves discrimination of the RAI for AKI

Model	NRI						IDI
	NRI Event	P Value	NRI Nonevent	P Value	Total NRI	P Value	IS	P Value	IP	P Value	Total IDI	P Value
RAI+NGAL	−0.035	0.85	0.546	<0.001	0.512	0.01	0.023	0.13	−0.004	0.32	0.027	0.08
RAI+MMP-8	−0.172	0.35	0.600	<0.001	0.428	0.03	0.025	0.30	−0.004	0.15	0.029	0.23
RAI+Ela-2	0.172	0.35	0.373	<0.001	0.545	0.01	0.065	0.07	−0.010	0.05	0.075	0.03
RAI+NGAL+MMP-8	0.103	0.58	0.503	<0.001	0.606	0.002	0.058	0.06	−0.009	0.05	0.067	0.02
RAI+NGAL+Ela-2	0.379	0.04	0.492	<0.001	0.871	<0.001	0.086	0.02	0.014	0.03	0.100	0.01
RAI+MMP-8+Ela-2	0.172	0.35	0.459	<0.001	0.632	0.002	0.067	0.06	−0.011	0.04	0.078	0.02

The prediction model of the RAI for day 3 AKI was used as the reference model for evaluating the models incorporating biomarkers NGAL, MMP-8, and Ela-2 individually and in combination. NRI and IDI values shown represent the total effect for both events (with day 3 AKI) and nonevents (without day 3 AKI). IP, difference of integral of 1-specificity between models; IS, difference of integral of sensitivity between models.