Table 4.
Metabolic parameters according to acid base status in the SCA subgroup
| Parameter | Acidosis (n=14) | No Acidosis (n=51) | P Value |
|---|---|---|---|
| Plasma | |||
| Measured GFR (ml/min per 1.73 m2) | 115.4±22.1 | 121.3±30.2 | 0.43 |
| K+ (mmol/L) | 4.2±0.4 | 4.1±0.3 | 0.4 |
| Plasma phosphate (mg/dl) | 4.0±0.8 | 3.7±0.6 | 0.26 |
| Plasma uric acid (mg/dl) | 7.0±2.0 | 6.3±1.7 | 0.43 |
| Blood glucose (mg/dl) | 90.6±8.8 | 87.9±7.9 | 0.34 |
| HCO3− (mmol/L) | 21.7±0.9 | 25.6±1.6 | <0.001 |
| Venous pH | 7.31±0.03 | 7.34±0.04 | 0.03 |
| PvCO2 (mmHg) | 44.9±4.7 | 49.7±6.5 | 0.01 |
| PvO2 (mmHg) | 48.4±13.1 | 47.7±12.1 | 0.99 |
| Plasma renin (pg/ml) | 59.6±86.5 | 21.6±18.8 | 0.12 |
| Plasma aldosterone (pg/ml) | 77.0±63.6 | 79.3±71.2 | 0.67 |
| Aldosterone/renin ratio | 3.4±3.1 | 5.7±5.1 | 0.08 |
| Urine | |||
| Urine aldosterone (µg/24 h) | 7.4±6.0 | 8.0±7.1 | 0.94 |
| Fasting urine pH | 5.5±0.4 | 5.9±0.6 | 0.02 |
| Fasting urine PCO2 (mmHg) | 32.7±9.9 | 38.6±8.7 | <0.01 |
| Fasting bicarbonaturia (mmol/L) | 0.6±0.8 | 3±9.2 | 0.01 |
| Fasting ammonium excretion (µmol/min) | 25.8±18.7 | 19.4±11.5 | 0.26 |
| Sodium excretion (mmol/24 h) | 90±52 | 122±62 | 0.06 |
| Potassium excretion (mmol/24 h) | 27±12 | 35±18 | 0.19 |
| Urine phosphate (mg/24 h) | 47.1±20.5 | 48.4±24.6 | 0.84 |
| Urine uric acid (mg/24 h) | 49.9±20.0 | 59.8±33.4 | 0.36 |
| Estimated protein intake (g/kg per 24 h) | 0.85±0.39 | 0.85±0.39 | 0.95 |
| Ammonium excretion (mmol/24 h) | 22.2±7.4 | 19.1±12.6 | 0.12 |
| Estimated titratable acid (mmol/24 h) | 10.2±5.0 | 8.1±5.3 | 0.24 |
| Net acid excretion (mmol/24 h) | 32.5±10.3 | 27.3±16.7 | 0.12 |
| 24-h urine pH | 5.8±0.5 | 6.3±0.5 | 0.002 |
| Urine output (ml/24 h) | 1533±599 | 1771±709 | 0.22 |
Data are presented as the mean±SD.