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. Author manuscript; available in PMC: 2014 Apr 3.
Published in final edited form as: Leukemia. 2011 Sep 16;26(4):708–715. doi: 10.1038/leu.2011.255

Table 1.

Sequence alignment of the ‘gatekeeper’ region of tyrosine kinases with common mutations that confer drug resistance compared to JAK2.

Tyrosine kinase Protein sequence ‘Gatekeeper’ mutation
ABL PFYIIT315EFMTYGNLLDYLR T315I 20
EGFR TVQLIT790QLMPFGCLLDYVR T790M 21
KIT PTLVIT670EYCCYGDLLNFLR T670I 23
PDGFRα PIYIIT674EYCFYGDLVNYLH T674I 19
hJAK2 NLKLIM929EYLPYGSLRDYLQ
mJAK2 --R---929-------------