. 2014 Apr 7;20(13):3516–3524. doi: 10.3748/wjg.v20.i13.3516

Table 1.

Virologic and clinical outcomes of hepatitis B virus infection in patients with inflammatory bowel disease undergoing immunosuppressive therapy

Ref.	Disease	Age/sex	HBsAg status	HBV-DNA before therapy	Anti-TNFα	Contemporary drugs	LAM prophylaxis	HBV-DNA reactivation	Biochemical reactivation
Esteve et al[66]	CD	34 M	+ IC	NA	IFX	AZT	No	Yes	ALT 2089
Esteve et al[66]	CD	34 M	+ IC	NA	IFX	AZT	No	10.400 pg/mL	AST 1561
	CD	38 M	+ IC	NA	IFX	AZT	No	Yes	ALT 2225
	CD	38 M	+ IC	NA	IFX	AZT	No	9000 pg/mL	AST 2146
	CD	26 M	+ CH	Positive	IFX	AZT	Yes	No	No
del Valle et al[61]	CD	40 M	+ CH	Positive	IFX	AZT	No	No worsening	No
del Valle et al[61]	CD	40 M	+ CH	3.9 × 10⁵ copies/mm³	IFX	AZT	No	No worsening	No
Ueno et al[64]	CD	28 F	+ IC	NA	IFX	AZT	No	Yes	ALT 43
Ueno et al[64]	CD	28 F	+ IC	NA	IFX	AZT	No	4.5 LEG/mL	AST 64
Millonig et al[12]	CD	50 M	+ IC	Positive	IFX	AZT	No	Yes	ALT 983/50
Millonig et al[12]	CD	50 M	+ IC	20 IU/mL	IFX	AZT	No	38000000 UI/mL	AST 413/50
Colbert et al[10]	CD	54 M	+ IC	NA	IFX	AZT	No	Yes	ALT 124
Colbert et al[10]	CD	54 M	+ IC	NA	IFX	AZT	No	1.604 pg/mL	AST 143
Madonia et al[13]	CD	41 F	- OC	NA	IFX	Steroids	No	Yes	ALT × 10 UNL
Madonia et al[13]	CD	41 F	- OC	NA	IFX	Steroids	No	Yes	AST × 6 UNL
Ojiro et al[63]	CD	43 F	+ IC	NA	IFX	AZT	No	Yes	ALT 239
Ojiro et al[63]	CD	43 F	+ IC	NA	IFX	AZT	No	5.4 LGE/mL	AST 145
Zeitz et al[11]	UC	43 M	NA	NA		Steroids + AZT	No	Yes	ALT 3396
Zeitz et al[11]	UC	43 M	NA	NA		Steroids + AZT	No	110000000 UI/mL	AST 2193

CD: Crohn’s disease; UC: Ulcerative Colitis; IC: Inactive carrier; OC: Occult carrier; NA: Not available; CH: Chronic hepatitis; IFX: Infliximab; AZT: Azathioprine; LGE: Logarithm genome equivalent; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; TNFα: Tumor necrosis factor alpha; LAM: Lipoarabinomannan.