Fig. 4.

Experimental evaluation of the binding model. (A) Cells were infected with different MV recombinants and incubated in the presence of a range of OX-1 concentrations as indicated, followed by TCID₅₀ titration to determine virus yields. IC₅₀ values are given. (B) Quantitative inhibition assay of cells cotransfected with MV-H and MV-F variants as indicated, followed by incubation in the presence of compound. Values reflect inhibition of fusion and were normalized for fusion observed in the absence of compound. (C) Cells infected with MV-Edm were incubated in the presence of a panel of OX-1 variants as indicated and subjected to TCID₅₀ titration.