Table 4.

Univariate and multivariate analyses of factors affecting overall survival

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age (over 65 years old)	0.95	0.8640	0.98	0.9460
	(0.53-1.73)		(0.48-2.01)
CEA ≥ 3.85 ng/mL	1.72	0.0827	1.49	0.2650
	(0.93-3.28)		(0.74-3.07)
CA19-9 ≥ 56.8 U/mL	2.61	0.0030	1.98	0.0798
	(1.38-5.15)		(0.92-4.36)
Tumor size (> 20 mm)	1.46	0.2420	3.27	0.0283
	(0.78-2.88)		(1.13-10.1)
Portal vein invasion	1.88	0.0487	0.67	0.3640
	(1.00-3.49)		(0.28-1.59)
UICC ≥ IIB	1.57	0.1210	0.78	0.5030
	(0.89-2.88)		(0.37-1.62)
R1/R0	2.59	0.2590	2.29	0.3460
	(0.41-8.96)		(0.36-9.38)
Adjuvant chemotherapy	0.68	0.2040	0.46	0.0312
	(0.38-1.24)		(0.23-0.93)
EUS-FNA	0.46	0.0093	0.44	0.0365
	(0.26-0.83)		(0.20-0.95)

UICC: Pathological stage of the Union Internationale Contre le Cancer; EUS-FNA: Endoscopic-ultrasound-guided fine-needle aspiration.