Table 5.

Univariate and multivariate analyses of factors affecting relapse-free survival after surgery

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age (over 65 years old)	0.81	0.8640	0.84	0.6300
	(0.47-1.43)		(0.42-1.68)
CEA ≥ 3.85 ng/mL	1.28	0.0827	1.12	0.7360
	(0.72-2.28)		(0.57-2.19)
CA19-9 ≥ 56.8 U/mL	2.58	0.0030	2.34	0.0798
	(1.43-4.82)		(1.14-4.92)
Tumor size (> 20 mm)	1.67	0.2420	3.31	0.0254
	(0.92-2.28)		(1.15-10.3)
Portal vein invasion	2.12	0.0123	0.61	0.2752
	(1.18-3.78)		(0.24-1.47)
UICC ≥ IIB	2.44	0.0016	1.97	0.0588
	(1.39-4.42)		(0.98-4.16)
R1/R0	1.98	0.2590	1.96	0.4266
	(0.32-6.54)		(0.29-7.60)
Adjuvant chemotherapy	0.78	0.2040	0.43	0.0168
	(0.44-1.40)		(0.22-0.85)
EUS-FNA	0.5	0.0150	0.46	0.0606
	(0.29-0.87)		(0.20-1.03)

UICC: Pathological stage of the Union Internationale Contre le Cancer; EUS-FNA: Endoscopic ultrasound-guided fine-needle aspiration.