Table 4.
Logistic regression model for the increased risk of developing irritant contact dermatitis due to atopic dermatitis (AD) and filaggrin gene (FLG) loss-of-function mutations
| ADa | FLG loss-of-function mutation | ||||
|---|---|---|---|---|---|
| Total Nb | No n (%) | Yes n (%) | No n (%) | Yes n (%) | |
| Controls | 393 | 308 (81.3%) | 71 (18.7%) | 299 (91.7%) | 27 (8.3%) |
| Patients | 634 | 361 (59.2%) | 249 (40.8%) | 499 (84.1%) | 94 (15.9%) |
| Adjusted odds ratio (95% confidence interval)c | 2.89 (2.08 – 4.03)* | 1.61 (1.01 – 2.58)* | |||
a
AD was defined by current or past flexural eczema
b
Subgroup totals may not add up to the total N due to genotyping failures and/or missing data on flexural eczema
c
Adjusted for AD and FLG mutations, respectively
*
Significant at p < 0.05