Table 1. Subject Characteristics (mean ± standard deviation).

	Baseline Age (yrs)	Follow-Up Interval (yrs)*	HDRS Baseline	HDRS Post-8 Week Treatment	HDRS 2 Year Follow-Up
Controls Range	72 ± 6	2.5 ± 0.2 (2.3 - 2.9)	0.4 ± 0.8 (0 - 2)		0.7 ± 0.9 (0 – 2)
Patients range	68 ± 8	1.9 ± 0.3 (1.5 - 2.5)	25.1 ± 2.7 (21 - 30)	5.9 ± 4.7 (0-12)	7.4 ± 7.9 (1 - 23)

	Response / Non-Response Post-8 Week Treatment	Sustained Response / Relapse at 2 Year Follow-Up	Treated / Untreated at 2 Year Follow-Up
Patients	8 / 1	7 / 2	6 / 3

	MMSE Baseline	MMSE Post-8 Week Treatment	MMSE 2 Year Follow-Up	DRS Baseline	DRS Post-8 Week Treatment	DRS 2 Year Follow-Up
Controls	28.9 ± 0.9	28.8 ± 1.0	28.8 ± 1.0	137.6 ± 3.9	138.8 ± 3.4	141.7 ± 1.6
Patients	28.8 ± 1.0	29.2 ± 1.3	29.4 ± 0.9	141.7 ± 2.9	141.9 ± 1.7	141.3 ± 3.3

	CVLT Trials 1 – 5 Baseline	CVLT Trials 1 – 5 Post-8 Week Treatment	CVLT Trials 1 – 5 2 Year Follow-Up	COWAT Baseline	COWAT Post-8 Week Treatment	COWAT 2 Year Follow-Up
Controls	42.9 ± 9.8	47.3 ± 13.8	50.7 ± 13.3	37.7 ± 12.1	44.3 ± 14.6	38.4 ± 15.1
Patients	46.6 ± 7.3	52.2 ± 7.2	50.6 ± 8.1	39.1 ± 7.8	40.7 ± 7.9	46.8 ± 11.9

^*Difference significant p < 0.05

HRDS: Hamilton Depression Rating Scale, MMSE: Mini-Mental State Examination, DRS: Dementia Rating Scale, CVLT: California Verbal Learning Test, COWAT: Controlled Oral Word Association Test