TABLE 4.
Alcohol use disorder phenotype | Proportion of variation
|
Correlations between factors explaining variation in risk for disordered gambling and alcohol use disorder
|
||
---|---|---|---|---|
Additive genetic | Unique environment | Genetic correlations | Environmental correlations | |
Full sample | ||||
DSM-IV alcohol dependencea | 0.48 (0.35, 0.61) | 0.52 (0.39, 0.65) | 0.44 (0.33, 0.49) | 0.32 (0.13, 0.42) |
DSM-5 alcohol use disordera | 0.50 (0.42, 0.57) | 0.51 (0.43, 0.58) | 0.29 (0.16, 0.36) | 0.37 (0.28, 0.42) |
DSM-IV AUD symptom countb | 0.43 (0.38, 0.48) | 0.57 (0.52, 0.62) | 0.35 (0.32, 0.38) | 0.22 (0.17, 0.27) |
Men | ||||
DSM-IV alcohol dependencea | 0.41 (0.22, 0.61) | 0.58 (0.39, 0.78) | 0.46 (0.31, 0.52) | 0.35 (0.08, 0.45) |
DSM-5 alcohol use disordera | 0.52 (0.40, 0.65) | 0.48 (0.37, 0.59) | 0.30 (0.08, 0.39) | 0.42 (0.32, 0.46) |
DSM-IV AUD symptom countb | 0.49c (0.41, 0.56) | 0.51 (0.44, 0.59) | 0.41d (0.38, 0.43) | 0.25 (0.17, 0.31) |
Women | ||||
DSM-IV alcohol dependencea | 0.54 (0.36, 0.72) | 0.46 (0.28, 0.64) | 0.39 (0.16, 0.48) | 0.25 (−0.18, 0.40) |
DSM-5 alcohol use disordera | 0.47 (0.35, 0.58) | 0.54 (0.43, 0.65) | 0.28 (0.04, 0.37) | 0.27 (0.01, 0.37) |
DSM-IV AUD symptom countb | 0.38c (0.31, 0.44) | 0.66 (0.56, 0.69) | 0.29d (0.24, 0.34) | 0.20 (0.11, 0.26) |
Note:
Using categorical 1+ symptom phenotype of disordered gambling;
using continuous disordered gambling phenotype, 95% confidence intervals are in parentheses.
Parameter estimate differed for men and women, Δχ2 = 8.72, df = 1, p = .003.
Parameter estimate differed for men and women, Δχ2 = 13.82, df = 1, p = .0002.