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. 2014 Apr 3;10(4):e1004235. doi: 10.1371/journal.pgen.1004235

Figure 4. Effects of disrupted GRB10 through knock-down on islet function.

Figure 4

(A) Disrupted GRB10 in INS-1 rat β-cells markedly reduced glucose-stimulated insulin secretion. (B) GRB10 knock-down showed reduced glucose-stimulated insulin secretion at 20 mM glucose and glucagon secretion at 1 mM glucose in human pancreatic islets (Ninsulin = 7, Nglucagon = 6 donors of human pancreatic islets; 3–6 measurements in each experiment for each donor). (C) GRB10 knock-down resulted in a reduction of insulin and glucagon mRNA expression (N = 3 donors of human pancreatic islets; 3 measurements in each experiment for each donor). * p<0.05; ** p<0.01, *** p<0.001. Error bars denote SEM.