Figure 7. Occurrence of transient non-native contacts along the conformational transition of Glt_Ph between iOF and IF states.

A. Distances of three contact-forming pairs plotted against the index of the conformers along the pathway. All contacts are formed between residues belonging to the same protomer. Two residues are said to form a non-native contact if they are more than 10 Å apart in the reference states but somewhere along the transition, the pairwise distance between them becomes less than 7 Å. B. Conformer at the point of closest contact between Val62 and Ala353 (lowest point of the red curve in A, corresponding to the image 46). The contact forming residues, Val62 and Ala353 are shown as blue and red spheres respectively. The color code is: trimerization domain, cyan; TM3, deep sky blue; TM6, lime; HP1, yellow; TM7, orange; HP2, orange; TM8, magenta and the rest, gray.