Table 3. Most highly induced or down-regulated genes in SK-N-SH cells over-expressing MECP2_e1 or MECP2_e2.

SK-N-SH Cells
MECP2_e1 over-expression						MECP2_e2 over-expression
Up-regulated			Down-regulated			Up-regulated			Down-regulated
Gene	FC	qPCR	Gene	FC	qPCR	Gene	FC	qPCR	Gene	FC	qPCR
BCL11A	11.4	N/A	FLG	15.8	N/A	PSCD4	6.7	N/A	HS8ST3	5.4	N/A
PRLR	10.5	N/A	CCL2	13.9	N/A	BCL11A	6.0	N/A	NR0B1	5.0
AMOT	10.3	N/A	CRH	11.5	?	PGK2	5.6	N/A	NEFM	4.6
FGB	10.3	N/A	THBD	10.6	N/A	NAV3	5.5		LRRN3	4.5	N/A
CTTNBP2	10.1	N/A	IL8	9.2	N/A	GJB2	5.4	N/A	LGICZ1	3.5
CD46	10.1	N/A	CRTC1	8.3	N/A	SIRPG	5.1	N/A	GRM8	3.4
PTGS4	8.9	N/A	NR0B1	8.1		IGSF10	5.0	N/A	MAP2K6	3.4	N/A
PGK2	8.9	N/A	PLAU	6.5	N/A	DPEP1	5.0	N/A	MYOD1*	3.4	N/A
MYPN	8.7	N/A	CST2	6.4	N/A	KIR2DS4	4.8	N/A	SIX2	3.3	N/A
PLXNC1	8.5	N/A	IL1B	6.3	N/A	XAGE5	4.7	N/A	OTUD6A	3.3	N/A
PTPLAD2	8.5	N/A	ELAVL3	6.2	✓	SDPR	4.7	N/A	DHDH	3.2	N/A
FLVCR2	8.4	N/A	IVL	6.1	N/A	TBX1	4.6	N/A	PDK4	3.2	N/A
CFHR1	8.3	N/A	RGS33	6.0	N/A	CLEC4D	4.6	N/A	VMAC	3.1	N/A
DNAH11	8.2	N/A	NOV	6.0	N/A	CYP2E1	4.5	N/A	FMN2	3.1	✓
GRAP	8.1	N/A	SFTPA1	5.8	N/A	SLFN12	4.4	N/A	RHEB	3.0	N/A
ECM2	7.8	N/A	KLK6	5.8	N/A	FOXP2	4.4	✓	HIST1H2AC	3.0	N/A
LRIG3	7.8	N/A	OTOR	5.7	N/A	TUBB1	4.4	N/A	SYTL3	2.9	N/A
TMPRSS5	7.7	N/A	FAM84A	5.6	N/A	ARHGAP30	4.4	N/A	CYP4F2	2.9	N/A
FAM110C	7.6	N/A	PDGFC	5.6	N/A	ADH1A	4.4	N/A	ING1	2.9	N/A
LMX1B	7.5	N/A	EFEMP1	5.5	N/A	F2RL1	4.3	N/A	PSMD8	2.9	N/A

FC = fold change by microarray.

N/A = qPCR validation was not done.

✓ = qPCR results are in agreement with microarray results.

 = qPCR results contradict microarray results.

? = qPCR results were inconclusive.

* = similar change was observed in mouse Mecp2 knockout fibroblasts.