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. 2014 Apr 3;9(4):e90231. doi: 10.1371/journal.pone.0090231

Figure 7. Regulation of miRNA expression in LPS-conditioned moDCs.

Figure 7

When moDCs are exposed to LPS, activated NF-κB p65 induces H3K4me3 redistribution from the TSS to miRNA-coding region by interacting with p300 and RBBP4/RBBP7. Meanwhile, activated NF-κB transcription factors (such as p65, p52, p50, C-rel and CrelB) bind to promoter regions and initiate miRNA expression. AP-1 components Jun and c-fos, which are activated by LPS, also bind with the miR-146a and miR-155 promoters to induce miR-155 and miR-146a gene expression.