Figure 5. The effects of different ARBs on the cardiac function and Src expression in AGT KO mice.
AGT KO mice were induced by AngII or TAC for 2 weeks with or without the pretreatment of valsartan or candesartan. (A) Representative M-mode tracings of AGT KO hearts stimulated by AngII (10−5 mol/L, top line) or by TAC for 2 weeks (bottom line). (B) Representative recording of LVAWd, LVPWd and LVEF in AGT KO mice from each group. (C) The expression of Src in myocardium of AGT KO mice from each group was determined. Data were presented as mean ± s.e.m. from five to eight mice. * P<0.05 vs. AngII-treated AGT KO mice; # P<0.05 vs. TAC-treated AGT KO mice.