Table 3.

Mean (±SEM) baseline serum sclerostin, adjusted for season, by tertile of selected variables in 314 subjects

	Men			Women
	Tertile boundaries	Sclerostin, ng/L	P	Tertile boundaries	Sclerostin, ng/L	P
25-hydroxyvitamin D, nmol/L	< 69.9	26.8 ± 2.9	0.420	<52.4	25.8 ± 1.8	0.690
	69.9 – 97.3	31.6 ± 3.0		52.4 – 74.8	27.7 ± 1.9
	≥ 97.4	31.4 ± 2.7		≥ 74.9	27.7 ± 1.7
PTH, pmol/L	< 2.9	31.7 ± 2.7	0.445	< 3.3	25.4 ± 1.8	0.556
	2.9 – 4.2	31.0 ± 2.8		3.3 – 4.4	27.7 ± 1.7
	≥ 4.3	27.2 ± 2.7		≥ 4.5	27.9 ± 1.7
Serum osteocalcin, nmol/L	< 0.8	26.9 ± 2.6	0.008	< 1.0	25.4 ± 1.7	0.249
	0.8 – 1.0	26.3 ± 2.7		1.0 – 1.3	29.3 ± 1.7
	≥ 1.1	36.9 ± 2.7a		≥ 1.4	26.5 ± 1.7
Bone mineral density (BMD), g/cm2
Femoral neck	< 0.90	28.2 ± 2.9	0.712	< 0.75	29.4 ± 1.8	0.108
	0.90 – 1.00	29.9 ± 2.6		0.75 – 0.83	24.4 ± 1.7
	≥ 1.01	31.5 ± 2.7		≥ 0.84	27.7 ± 1.7
L2-L4 spine	< 1.20	29.3 ± 2.8	0.673	< 0.93	28.5 ± 1.8	0.667
	1.20 – 1.36	28.7 ± 2.8		0.93 – 1.08	26.2 ± 1.8
	≥ 1.37	32.1 ± 2.9		≥ 1.09	27.7 ± 1.8
Total body	< 1.16	26.6 ± 2.7	0.231	< 0.97	27.5 ± 1.8	0.939
	1.16 – 1.23	30.3 ± 2.7		0.97 – 1.05	27.2 ± 1.7
	≥ 1.24	33.2 ± 2.8		≥ 1.06	26.6 ± 1.7
Bone mineral content (BMC), g
Total body	< 2774	28.6 ± 2.7	0.437	< 1770	27.1 ± 1.8	0.749
	2774 – 3116	28.5 ± 2.8		1770 – 2041	28.0 ± 1.7
	≥ 3117	32.9 ±2.8		≥ 2042	±1.7

^aDiffers from other two tertiles at P = 0.007.