Table 2.
Gender-stratified characteristics of leptin receptor–deficient ( db/db ) mice and wild-type (C57B6/J) littermates
| |
Male |
Female |
||
|---|---|---|---|---|
| C57B6/J # (n = 8) | db/db # (n = 8) | C57B6/J (n = 6) | db/db (n = 5) | |
| Body weight (g) |
36.50 ± 1.46 |
62.50 ± 3.33** |
35.00 ± 0.84 |
57.80 ± 4.84** |
| Glucose (mg/dL) |
206.88 ± 10.74 |
398.00 ± 19.89** |
219.17 ± 9.04 |
307.20 ± 41.11* |
| TC (mg/dL) |
74.63 ± 4.69 |
188.88 ± 16.00** |
73.17 ± 2.23 |
183.60 ± 10.80** |
| TG (mg/dL) |
47.13 ± 5.78 |
52.88 ± 6.24 |
41.33 ± 8.10 |
49.40 ± 7.05 |
| HDL-C (mg/dL) |
51.00 ± 3.29 |
97.25 ± 8.24** |
50.83 ± 2.82 |
89.60 ± 7.92** |
| LDL-C (mg/dL) | 14.20 ± 1.89 | 81.05 ± 11.29** | 14.07 ± 4.08 | 84.12 ± 6.04** |
Values represent the mean ± standard error of the mean. TC total cholesterol; TG triglyceride; HDL-C HDL cholesterol; LDL-C LDL cholesterol. Variation between groups was determined by using the two-independent-sample test with the Mann–Whitney U test for comparisons. *P < 0.05, **P < 0.01 vs gender-matched control group. #No parameter was significantly different from that of female mice of the same genotype.