Table 2. Examples of endoxifen sensitivity associated gene/miRNA expression identified in YRI and replicated in CEU LCLs.

SNP	miRNAs	genes	p-S1		p-S2		p-S3		p-S4		p-S5		p-S6
			YRI	CEU	YRI	CEU	YRI	CEU	YRI	CEU	YRI	CEU	YRI	CEU
rs4386686	let-7i	TRAF1	1.5×10−2	3.3×10−2	6.5×10−3	7.3×10−3	6.3×10−5	NS	3.0×10−5	NS	2.0×10−2	NS	7.3×10−5	NS
rs4700416	let-7i	TRAF1	1.5×10−2	3.3×10−2	6.5×10−3	7.3×10−3	6.3×10−5	NS	3.0×10−5	NS	2.0×10−2	NS	7.3×10−5	NS
rs17104213	miR-363	AMPD3	4.0×10−2	2.7×10−3	2.0×10−3	2.6×10−2	1.9×10−5	3.9×10−5	3.0×10−6	NS	4.2×10−2	NS	6.4×10−5	NS
rs12915737	miR-363	LARGE	1.6×10−2	2.7×10−2	2.0×10−3	2.6×10−2	1.1×10−5	1.8×10−5	9×10−5	NS	3.1×10−4	NS	5.6×10−5	NS

p-S1, p-S2, p-S3, p-S4, p-S5 and p-S6 are short for p-values of each step, from step 1 to step 6. Step 1, the association between the phenotypes of endoxifen sensitivity and ∼13,000 gene/transcript cluster expressions; step 2, the association between the phenotypes of endoxifen sensitivity and 201 miRNA expressions; step 3, the negative correlation between mRNA and miRNA expressions from step 1 and step 2; step 4, the association between mRNA expressions from step 3 and SNP genotypes; step 5, the association between miRNA expression from step 3 and SNP genotypes from step 4; step 6, the association of SNP genotypes from step 5 and the phenotypes of endoxifen sensitivity. NS, not significant at p<0.05 threshold.