Table 2. Main effects of RNASEL rs486907 and MIR146A rs2910164 genotypes on non-melanoma skin cancer risk.
| BCC | SCC | ||||
| Controls | N | OR (95% CI)* | N | OR (95% CI)* | |
| RNASEL | |||||
| G/G | 288 | 370 | reference | 258 | reference |
| G/A | 362 | 375 | 0.85 (0.68–1.06) | 271 | 0.84 (0.66–1.07) |
| A/A | 106 | 113 | 0.88 (0.64–1.21) | 74 | 0.79 (0.56–1.13) |
| trend# | 0.91 (0.79–1.06) | 0.88 (0.74–1.04) | |||
| P for trend = 0.23 | P for trend = 0.12 | ||||
| MIR146A | |||||
| G/G | 481 | 567 | reference | 388 | reference |
| G/C | 271 | 281 | 0.88 (0.71–1.10) | 241 | 1.09 (0.87–1.38) |
| C/C | 43 | 44 | 0.80 (0.51–1.26) | 34 | 0.90 (0.55–1.48) |
| trend# | 0.89 (0.75–1.05) | 1.03 (0.85–1.23) | |||
| P for trend = 0.17 | P for trend = 0.79 | ||||
*Adjusted for age, sex, level of education, cigarette smoking status 1 year before the reference date (for SCC only), skin sensitivity (measured by skin reaction after 1 hour of sun exposure the first time in the summer) and the number of lifetime painful sunburns.
#
Trend for any variant allele.