Table 3. Main effects of RNASEL rs486907 and MIR146A rs2910164 genotypes on non-melanoma skin cancer risk stratified by sex.

	Controls		BCC				SCC
	Men	Women	Men		Women		Men		Women
	N	N	N	OR (95% CI)*	N	OR (95% CI)*	N	OR (95% CI)*	N	OR (95% CI)*
RNASEL
G/G	182	106	215	reference	155	reference	166	reference	92	reference
G/A	212	150	214	0.90	161	0.79	175	0.88	96	0.77
				(0.68–1.20)		(0.56–1.12)		(0.65–1.19)		(0.51–1.16)
A/A	67	39	56	0.76	57	1.09	43	0.68	31	0.91
				(0.50–1.16)		(0.66–1.80)		(0.43–1.08)		(0.50–1.64)
trend#				0.88		0.98		0.84		0.90
				(0.72–1.07)		(0.77–1.23)		(0.68–1.04)		(0.68–1.19)
				P-trend = 0.19		P-trend = 0.85		P-trend = 0.10		P-trend = 0.46
MIR146A
G/G	302	179	309	reference	258	reference	248	reference	140	reference
G/C	165	106	164	0.99	117	0.73	160	1.15	81	1.02
				(0.75–1.32)		(0.52–1.03)		(0.86–1.53)		(0.69–1.52)
C/C	19	24	31	1.62	13	0.29	21	1.13	13	0.76
				(0.88–2.98)		(0.14–0.61)		(0.57–2.23)		(0.35–1.63)
trend#				1.11		0.64		1.11		0.94
				(0.89–1.39)		(0.49–0.83)		(0.88–1.41)		(0.70–1.27)
				P-trend = 0.34		P-trend <0.001		P-trend = 0.38		P-trend = 0.68

*Adjusted for age, level of education, cigarette smoking status 1 year before the reference date (for SCC only), skin sensitivity (measured by skin reaction after 1 hour of sun exposure the first time in the summer), and the number of lifetime painful sunburns.

^#Trend for any variant allele.