Table 1. Cytotoxicity induced by resveratrol, pterostilbene and conjugate in noncancer (COS-1, CHO) and prostate cancer (PC-3, LNCaP) cell lines after 24 h exposure as determined by MTT assay.
| Cell lines | IC50 valuea | ||
| Resveratrol (μM)b | Pterostilbene (μM)b | Conjugate (μM)b | |
| PC-3 | 95.0±1.13 | 75±2.55 | 45±1.50c d |
| LNCaP | 82.2±2.19 | 66.4±1.39 | 40±1.12c d |
| COS-1 | >100 μM | >100 μM | >100 μM |
| CHO | >100 μM | >100 μM | >100 μM |
a
50% growth inhibition as determined by MTT assay (24 h drug exposure).
b
Compound tested in triplicate, data expressed as mean value ± SEM of three independent experiments.
c
p<0.001 between resveratrol and conjugate treated group.
d
p<0.001 between PTER and conjugate treated group.