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. 2014 Apr 3;9(4):e93764. doi: 10.1371/journal.pone.0093764

Figure 3. PKE and its compounds sensitize PC-3M-luc2 cells to TRAIL -induced apoptosis in vitro.

Figure 3

A) Cells treated with PKE in combination with increasing concentrations of human TRAIL (0−100 ng/ml), values are percentages of nuclear fragmentation. B) Cells treated with PKE, LS mixture, or with individual PKE compounds in combination with human TRAIL (25 ng/ml), values are relative apoptosis rates (Ctrl = 1). The cells were treated with test compounds for 48 hours and nuclear fragmentation was determined with flow cytometer. LS, mixture of main PKE lignans and stilbenes; MePS, pinosylvin monomethyl ether; NTG, nortrachelogenin; PS, pinosylvin; MR, matairesinol; Ab, abietic acid; RV, resveratrol. The data are means of three independent experiments ± SEM. Statistical significance was determined by non-parametric t-test for each treatment in comparison to respective vehicle treatment (Ctrl). *p<0.05, **p<0.01, ***p<0.001.