Table 2. Distribution frequency of CD44 genotypes in 561 healthy controls and 599 oral cancer patients.
| Variable | Controls (N = 561) n (%) | Patients (N = 595) n (%) | OR (95% CI) | AOR (95% CI) |
| rs1425802 | ||||
| AA | 194 (34.6%) | 197 (32.9%) | 1.00 | 1.00 |
| AG | 235 (41.9%) | 249 (41.6%) | 1.043 (0.799–1.362) | 1.150 (0.784–1.686) |
| GG | 132 (23.5%) | 153 (25.5%) | 1.141 (0.841–1.550) | 1.359 (0.871–2.120) |
| AG+GG | 367 (65.4%) | 402 (67.1%) | 1.079 (0.846–1.376) | 1.222 (0.861–1.732) |
| rs187115 | ||||
| AA | 403 (71.8%) | 336 (56.1%) | 1.00 | 1.00 |
| AG | 143 (25.5%) | 227 (37.9%) | 1.904 (1.476–2.456) * | 2.098 (1.448–3.039) * |
| GG | 15 (2.7%) | 36 (6.0%) | 2.879 (1.549–5.348) * | 2.988 (1.280–6.973) * |
| AG+GG | 158 (28.2%) | 263 (43.9%) | 1.996 (1.563–2.550) * | 2.191 (1.535–3.126) * |
| rs713330 | ||||
| TT | 467 (83.2%) | 507 (84.6%) | 1.00 | 1.00 |
| TC | 86 (15.4%) | 88 (14.7%) | 0.943 (0.683–1.301) | 0.950 (0.597–1.510) |
| CC | 8 (1.4%) | 4 (0.7%) | 0.461 (0.138–1.540) | 0.694 (0.102–4.702) |
| TC+CC | 94 (16.8%) | 92 (15.4%) | 0.902 (0.659–1.234) | 0.936 (0.594–1.476) |
| rs11821102 | ||||
| GG | 481 (85.7%) | 531 (88.6%) | 1.00 | 1.00 |
| GA | 75 (13.4%) | 63 (10.5%) | 0.761 (0.532–1.087) | 0.727 (0.437–1.210) |
| AA | 5 (0.9%) | 5 (0.8%) | 0.906 (0.261–3.148) | 1.227 (0.235–6.394) |
| GA+AA | 80 (14.3%) | 68 (11.4%) | 0.770 (0.545–1.088) | 0.756 (0.462–1.237) |
| rs10836347 | ||||
| CC | 487 (86.8%) | 522 (87.1%) | 1.00 | 1.00 |
| CT | 69 (12.3%) | 73 (12.2%) | 0.987 (0.695–1.403) | 0.975 (0.584–1.626) |
| TT | 5 (0.9%) | 4 (0.7%) | 0.746 (0.199–2.796) | 0.601 (0.071–5.077) |
| CT+TT | 74 (13.2%) | 77 (12.9%) | 0.971 (0.690–1.367) | 0.953 (0.577–1.575) |
| rs13347 | ||||
| CC | 295 (52.6%) | 287 (47.9%) | 1.00 | 1.00 |
| CT | 223 (39.8%) | 262 (43.8%) | 1.208 (0.949–1.537) | 1.334 (0.936–1.901) |
| TT | 43 (7.6%) | 50 (8.3%) | 1.195 (0.771–1.854) | 1.069 (0.555–2.058) |
| CT+TT | 266 (47.4%) | 312 (52.1%) | 1.206 (0.957–1.518) | 1.290 (0.918–1.811) |
The odds ratios (ORs) and with their 95% confidence intervals (CIs) were estimated by logistic regression models. The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models after controlling for age, gender, betel nut chewing, tobacco and alcohol consumption.
*p value <0.05 as statistically significant.