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. 2014 Apr 3;9(4):e93819. doi: 10.1371/journal.pone.0093819

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© 2014 Zhang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inhibitory effects of 25 excipients on imidapril hydrolase activity of recombinant CES1A1 (A) and on CPT-11 hydrolase activity of recombinant CES2 (B). The concentrations of imidapril and CPT-11 were 100 μM and 5 μM, and the concentrations of the tested excipients were 500 μM except that F68, EL35, RH40, lecithin, PVP and Sodium alginate were 100 μg/ml. Each column represents the mean ± SD. The control activity was 1.83 nmol/min/mg and 13.7 pmol/min/mg for CES1A1 and CES2, respectively.