Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Figure 3. EZH2-induced BRCA1 nuclear/cytoplasmic shuttling requires the activation of Akt-1. (A) Western blot analyses showed that the protein level of p-Akt-1(Ser473) was decreased by downregulation of EZH2 and inceased by IGF-1 treatment. (B) Immunocytochemistry analyses showed that activation of Akt-1 inversed EZH2-mediated BRCA1 nuclear/cytoplasmic shuttling (×400).
