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. Author manuscript; available in PMC: 2014 Apr 3.
Published in final edited form as: Int J Pept Res Ther. 2013 Mar;19(1):3–12. doi: 10.1007/s10989-012-9313-0

Table 1.

cis-3,4-Methanoproline enhances affinity of phosphopeptides and mimics for Stat3

# Substrate IC50 (nm) Reference
11 Ac-pTyr-Leu-Pro-Gln-Val-
 NH2 		739 ± 31 Coleman et al. 2005
12 Ac-pTyr-Leu-mPro-Gln-Val-
 NH2 		265 ± 14a Coleman et al. 2005
13 pCinn-Leu-Pro-Gln-NHBn 138 ± 8 Mandal et al. 2009b
14 pCinn-Leu-mPro-Gln-NHBn 68 ± 8 Mandal et al. 2009b
15 βMpCinn-Leu-Pro-Gln-
 NHBn		 70 ± 15 Mandal et al. 2011
16 βMpCinn-Leu-mPro-Gln-
 NHBn		 46 ± 5 Mandal et al. 2011
17 βMpCinn-Leu-Pro-Apa 154 ± 10 Mandal et al. 2011
18 βMpCinn-Leu-mPro-Apa 88 ± 11 Mandal et al. 2011

pCinn 4-phosphoryloxycinnamoyl, βMpCinn 4-phosphoryloxy-β-methylcinnamoyl, Apa (R)-4-aminopentamide

a

Commercially available mPro is a racemic mixture of enantiomers. Only the more active diastereomer was reported