Table 3.
# | Xaa | IC50 (nM)a | |
---|---|---|---|
17 | Proline | Pro | 154 ± 10 |
19 | Sarcosine | Sar | 1540 ± 34 |
18 | cis-3,4-Methanoproline | mPro | 88 ± 11 |
20 | 4,4-Dimethylproline | 4,4-Me2Pro | 155 ± 31 |
21 | 4,4-Difluoroproline | 4,4-F2Pro | 121 ± 16 |
22 | cis-4-Fluoroproline | cis-4-FPro | 246 ± 62 |
23 | trans-4-Hydroxyproline | trans-4-HOPro | 166 ± 10 |
24 | cis-4-Hydroxyproline | cis-4-HOPro | 220 ± 27 |
25 | trans-4-Methoxyproline | trans-4-MeOPro | 317 ± 14 |
Affinity was determined by fluorescence polarization (Coleman et al. 2005)