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. Author manuscript; available in PMC: 2014 Apr 3.

Published in final edited form as: Int J Pept Res Ther. 2013 Mar;19(1):3–12. doi: 10.1007/s10989-012-9313-0

Table 3.

Effect of 4-substituted prolines on the affinity of peptidic inhibitor βMpCinn-Leu-Xaa-Apa

#	Xaa		IC₅₀ (nM)^a
17	Proline	Pro	154 ± 10
19	Sarcosine	Sar	1540 ± 34
18	cis-3,4-Methanoproline	mPro	88 ± 11
20	4,4-Dimethylproline	4,4-Me₂Pro	155 ± 31
21	4,4-Difluoroproline	4,4-F₂Pro	121 ± 16
22	cis-4-Fluoroproline	cis-4-FPro	246 ± 62
23	trans-4-Hydroxyproline	trans-4-HOPro	166 ± 10
24	cis-4-Hydroxyproline	cis-4-HOPro	220 ± 27
25	trans-4-Methoxyproline	trans-4-MeOPro	317 ± 14

^a

Affinity was determined by fluorescence polarization (Coleman et al. 2005)