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. 2014 Apr 3;10(4):e1004056. doi: 10.1371/journal.ppat.1004056

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Five SCID mice and 1 wild-type mouse with the same genetic background (C3H/HeSnJ) were injected ip with 500 spirochetes of wild-type (WT), Vmp⁻, or reconstituted (Vmp⁺R) strains. Mice were sampled on days 1–12 post-infection and the numbers of spirochetes/ ml of blood were determined by QPCR. Growth rates of the three strains in SCID mice during three consecutive days of exponential growth were not significantly different based on linear regression analysis of the slopes (P = 0.1129).