Table 3. Statistical parametric mapping results of brain regions showing relative metabolism changes in patients with Kleine-Levin Syndrome KLS (n = 4, baseline) compared to healthy controls (n = 15).

	Hemisphere	Coordinates
Hypermetabolism in KLS	(L)eft/(R)ight	x	y	z	Z-score
Medial Frontal Gyrus	L	−6	60	−16	4.47
Medial Frontal Gyrus	R	12	64	12	4.46
Inferior frontal gyrus	R	48	4	24	3.67
Middle frontal gyrus	R	36	40	12	3.63
Middle frontal gyrus	R	60	30	28	3.63
Inferior Temporal Gyrus	R	52	−28	−22	4.17
Middle Temporal Gyrus	R	66	−24	−12	4.26
Superior Temporal Gyrus	R	54	6	2	3.46
Precuneus	R	24	−54	22	4.07
Posterior cingulate	L	−18	−56	18	3.49

Note. Coordinates x, y, z refer to the standard Talairach and Tournoux³³ stereotactic space. Activation peaks’ significance is reported at the voxel-level, thresholded at p ≤.001, with a cluster extent >50 voxels. Only the most representative voxels in each anatomical structure are displayed.