Table 4. Statistical parametric mapping results of brain regions showing relative metabolism changes during symptomatic episodes in patients with Kleine-Levin Syndrome KLS (n = 4, acute episode) compared to healthy controls (n = 15).

	Hemisphere	Coordinates
a. Hypermetabolism in KLS	(L)eft/(R)ight	x	y	z	Z-score
Inferior frontal gyrus	L	−42	12	22	3.54
Superior Medial Frontal	R	12	64	12	5.13
Superior Orbital Frontal	L	−18	18	−16	3.58
Supplementary motor area	R	12	0	54	4.62
Left Insula	L	−38	−2	4	3.93
Right Caudate Nucleus	R	12	14	−12	3 47
Inferior Temporal Gyrus	R	50	−26	−22	4.25
Superior Temporal Gyrus	R	54	4	2	3.79
Inferior Parietal Lobule	L	−48	−54	38	3.76
Postcentral Gyrus	L	−54	−2	42	3.52
Precentral Gyrus	L	−42	−8	40	3.61
Precentral Gyrus	L	−60	2	34	3.47
Precuneus	R	22	−52	22	4.29
Precuneus	L	−16	−54	16	3.96
Lingual gyrus	L	−18	−42	−2	3.28
b. Hypometabolism in KLS
Middle Occipital Gyrus	R	28	−96	8	4.40
Middle Occipital Gyrus	L	−22	−100	12	3.61
Angular Gyrus	R	38	−74	32	4.02
Inferior Parietal Gyrus	R	66	−44	24	3.63
Cuneus	L	−14	−104	−4	3.51

Note. Coordinates x, y, z refer to the standard Talairach and Tournoux³³ stereotactic space. Activation peaks’ significance is reported at the voxel-level, thresholded at p ≤.001, with a cluster extent >50 voxels. Only the most representative voxels in each anatomical structure are displayed.