Table 3. Characteristics of the 4 Subjects With Discordant Echo and CMR Determination of LVH.
| Subject 1 | Subject 2 | Subject 3 | Subject 4 | |
|---|---|---|---|---|
| Age at baseline study, y | 17 | 36 | 34 | 23 |
| Sex | Male | Male | Female | Male |
| Causal gene (mutation) | MYH7 (Arg663Cys) | MYBPC3 (Arg502Trp) | MYBPC3 (Glu258Lys) | MYH7 (Arg719Gln) |
| BSA, m2 | 2.3 | 1.8 | 1.8 | 1.9 |
| IVS, mm | ||||
| Echo | 10.0 | 10.4 | 9.4 | 9.7 |
| CMR | 8.0 | 9.0 | 9.0 | 11.5 |
| PWT, mm | ||||
| Echo | 9.5 | 9.0 | 8.9 | 10.2 |
| CMR | 9.5 | 6.6 | 7.6 | 12.6 |
| LVEF, % | 73 | 70 | 61 | 60 |
| MWT, mm | ||||
| Echo | 10.4 (M-IS) | 11.8 (M-IS) | 11.3 (B-AS) | 11.9 (M-IS) |
| CMR | 13.9 (M-I) | 13.5 (M-IS) | 13.1 (M-AS) | 12.6 (M-PW) |
| Echo quality | Fair | Poor | Poor | Good |
| CMR quality | Fair | Good | Excellent | Good |
| Time interval between echo and | 0 days | 0 days | 0 days | 0 days |
| CMR | ||||
| LGE | None | None | None | None |
| Global Ea, cm/s | 12.2 | 11.8 | 13.2 | 11.1 |
| ECG | Normal | T wave Inversions | Left atrial enlargement | Normal |
| Follow-up findings | Development of overt LVH over 24 mo | Unchanged LV wall thickness (by echo) over 63 mo | Unchanged LV wall thickness (by echo and CMR) over 48 mo | Pending (baseline study performed during final year of study period) |
B-AS indicates basal anteroseptum; BSA, body surface area; CMR, cardiac MRI; Ea, global early myocardial tissue Doppler relaxation velocity; Echo, echocardiography; IVS, interventricular septum; LGE, late gadolinium enhancement; LVEF, left ventricular ejection fraction; LVH, left ventricular hypertrophy; M-AS, anterior septum at midventricle; M-I, inferior wall at midventricle; M-IS, inferior septum at midventricle; M-PW, midventricle posterior wall; MWT, maximal wall thickness; and PWT, posterior wall thickness.