Figure 1.

Crystal Structure of RNase L

(A) Ribbons representation of the RNase L dimer. 2-5A and AMP-PNP ligands are shown as sticks.

(B) Top view of the RNase L dimer orientation shown in (A).

(C) Bottom view of the RNase L dimer orientation shown in (A). Left, ribbons and surface representation. Inset, zoom-in view of RNase active site residues. Catalytic residues of RNase L are depicted as pink sticks, and IRE1 residues found at equivalent positions are colored beige. Disordered regions are shown as dashed lines, and the RNase L-specific helix α1′ is shown in red.

See also Figure S1 and Table 1.