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. 2014 Feb 19;289(14):10084–10094. doi: 10.1074/jbc.M113.516278

FIGURE 2.

FIGURE 2.

NE induced GDF-15 expression in Sprague-Dawley rats. A, ELISA showing the GDF-15 levels in rat serum induced by NE in different doses. The level of serum GDF-15 elevated 3 h after NE injection, maintained a high level in 24 h, and declined to baseline in 72 h. B, ELISA revealed increased serum GDF-15 levels when treated with NE (both 1.2 and 2.4 mg/kg/day) for 12 h. C, Western blot revealed increased tissue GDF-15 levels when treated with NE (both 1.2 and 2.4 mg/kg/day) for 12 h. D, immunohistochemistry tissue section illustrating more GDF-15 expression in rat cardiomyocytes 24 h after NE (2.4 mg/kg/day) stimulation. Con or con, control, *, p < 0.05; n = 3.