FIGURE 5.
The MANG, MSSN, and MDAL α-subunit isoforms are similarly modulated by the β2-subunit. Shown is the voltage dependence of BKCa activation of MANG (A), MSSN (B), and MDAL (C) constructs in the presence (open symbols) or absence (closed symbols) of a β2-subunit construct with its N terminus deleted (β2ND), expressed as open probability of the channel (Po) (n = 6–12). The bath solution contained 10 μm (squares) or 100 μm (circles) Ca2+. Half-maximal activation voltage (V0.5) obtained from voltage-activation curves for MANG (D), MSSN (E), or MDAL (F) isoforms for each Ca2+ concentration with (open columns) or without (closed columns) β2ND-subunit. *, p < 0.01 compared with α-subunit alone.