TABLE 2.

Effect of β1-subunit on the open and closed dwell-times of different BK_Ca α-subunit N-terminal isoforms

Time constants (τ₁ and τ₂) are expressed in milliseconds. P₁ and P₂ are relative distributions of data under curves used to fit the results shown in Fig. 3.

Isoform	Open, mean ± S.E.		Closed, mean ± S.E.
	α	α + β1	α	α + β1
MANG
τ1	1.46 ± 0.09	2.82 ± 0.11a	1.2 ± 0.12	1.02 ± 0.07
P1	0.49 ± 0.06	0.13 ± 0.01a	0.13 ± 0.01	0.69 ± 0.03a
τ2	4.71 ± 0.08	34.15 ± 0.02a	35.55 ± 0.04	33.2 ± 0.23a
P2	0.51 ± 0.06	0.87 ± 0.01a	0.87 ± 0.02	0.31 ± 0.03a
MSSN
τ1	1.06 ± 0.22	1.10 ± 0.18	0.61 ± 0.08	0.54 ± 0.05
P1	0.32 ± 0.13	0.11 ± 0.01	0.36 ± 0.02	0.54 ± 0.02a
τ2	3.60 ± 0.92	20.28 ± 0.02a	29.02 ± 0.04	40.34 ± 0.26a
P2	0.78 ± 1.50	0.89 ± 0.01	0.64 ± 0.02	0.46 ± 0.03a
MDAL
τ1	1.45 ± 0.07	9.84 ± 0.05a	1.22 ± 0.09	1.54 ± 0.08b
P1	0.68 ± 0.06	0.48 ± 0.03a	0.27 ± 0.02	0.66 ± 0.04a
τ2	5.42 ± 0.15	32.13 ± 0.05a	35.35 ± 0.04	23.98 ± 0.28a
P2	0.32 ± 0.06	0.52 ± 0.03a	0.73 ± 0.02	0.34 ± 0.05a

^a p < 0.01 compared to α-subunit.

^b p < 0.05 compared with α-subunit.