TABLE 1.

Apparent affinities for cAMP binding and/or activation for CNBD-containing ion channels

Values are reported as averages with the corresponding standard deviation.

Protein	n	KD	KA	ΔH	K½	No. of experiments
		μm	μm−1	kcal/mol	μm
KcsA/MloK1 in detergent	0.55 ± 0.01	2.14 ± 0.18	0.47 ± 0.04	−11.27 ± 0.11		5
KcsA/MloK1 in nanodiscs	0.73 ± 0.05	0.15 ± 0.02	6.89 ± 1.20	−13.11 ± 0.58		6
MloK1a		0.08 ± 0.02
KcsA/MloK1 in liposomes					1.19 ± 0.49	4
MloK1 in liposomesb					0.06 ± 0.02
CNBDa	0.98 ± 0.12	0.10 ± 0.01

^a Values were taken from Cukkemane et al. (34).

^b Value was taken from Nimigean et al. (25).