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. 2014 Feb 11;289(14):9560–9572. doi: 10.1074/jbc.M114.547687

FIGURE 6.

FIGURE 6.

Adipose deficiency of FIT2 in ob/ob mice results in reduced adiposity and unilocular LDs in BAT. A, gross anatomical view of a 10-week-old control (LL/obob) and an adipose-specific FIT2 knock-out mouse on the ob/ob genetic backround (AF2KO/obob) indicates reduced white adipose mass. B, quantification of body weights. C, quantification of wet weights of adipose depots and livers from LL/obob and AF2KO/obob mice. Circles and triangles, L/L and AF2KO, respectively. D, histological sections of EWAT from LL/obob and AF2KO/obob mice stained with H&E or immunolocalization of F4/80. The sections shown for H&E and F4/80 are non-consecutive. E, histological sections of BAT from LL/obob and AF2KO/obob mice stained with H&E show the appearance of larger unilocular LDs in AF2KO BAT than in LL/obob BAT. Data are represented as mean ± S.D. (error bars) (n = 5–8 mice/genotype). ***, p < 0.0001; ns, not significant.