FIGURE 2.

Impaired motor coordination and locomotion in Scly^−/−Sepp1^−/− mice. A, experimental timeline for behavioral testing. B, mean (± S.E.) latency to fall off rotorod. C, mean (±S.E.) time spent in inner and outer regions of the open field test. D, mean (± S.E.) distance traveled during the open field test. E, mean (± S.E.) time spent in the open and closed arms as well as the center during the elevated plus maze test. F, mean (± S.E.) distance traveled during the open field test. **, p < 0.01; ***, p < 0.001 compared with wild-type; #, p < 0.05 compared with Sepp1^−/−. Error bars represent S.E.