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. 2014 Feb 11;289(14):9662–9674. doi: 10.1074/jbc.M113.540682

FIGURE 9.

FIGURE 9.

Quantification and schematic representation of silver staining in Scly−/−Sepp1−/− mice. A, mean (± S.E.) optical density of silver staining in the red nucleus parvicellular part, ventrolateral lemniscus, decussation of the cerebellar peduncle, and inferior colliculus. B–E, schematic representation of brain regions exhibiting silver staining in Scly−/−Sepp1−/− mice superimposed upon coronal Nissl-stained brain sections representing levels at 2.70 (B), 3.28 (C), 4.48 (D), 4.96 (E), and 5.88 mm (F) posterior to bregma. Regions shaded gray indicate areas where silver staining was quantified and observed to be significantly elevated in Scly−/−Sepp1−/− mice. Regions shaded white represent areas where silver staining was observed to a lesser degree in Scly−/−Sepp1−/− mice. Abbreviations: BIC, brachium of the inferior colliculus; cwm, cerebellar white matter; Gi, gigantocellular reticular nucleus; icp, inferior cerebellar peduncle; MGN, medial geniculate nucleus; PR, prerubral field; RPC, red nucleus parvicellular part; scp, superior cerebellar peduncle; ts, tectospinal tract; VLL, ventrolateral lemniscus; XSCP, decussation of the cerebellar peduncle. *, p < 0.05; **, p < 0.01 compared with wild-type mice; #, p < 0.05 compared with Sepp1−/− mice. Error bars represent S.E.