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. 2014 Feb 7;289(14):9795–9810. doi: 10.1074/jbc.M113.527150

FIGURE 5.

FIGURE 5.

Lack of Fgf-23 results in up-regulation of HIF target genes. A–D, quantitative real time RT-PCR showing changes in liver transferrin (A, WT, n = 6; Fgf-23−/−, n = 5), transferrin receptor (B, WT, n = 6; Fgf-23−/−, n = 5), glucose transporter-1 (C, WT, n = 6; Fgf-23−/−, n = 5), and phosphoglycerate kinase-1 (D, WT, n = 6; Fgf-23−/−, n = 5) mRNA expression in WT and Fgf-23−/− mice. E–H, quantitative real time RT-PCR showing changes in bone marrow transferrin (E, WT, n = 6; Fgf-23−/−, n = 6), transferrin receptor (F, WT, n = 6; Fgf-23−/−, n = 6), glucose transporter-1 (G, WT, n = 6; Fgf-23−/−, n = 6), and phosphoglycerate kinase-1 (H, WT, n = 5; Fgf-23−/−, n = 5) mRNA expression in WT and Fgf-23−/− mice. The data are represented as mean fold change ± S.E. relative to housekeeping gene HPRT. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

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