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. 2014 Apr;24(4):545–553. doi: 10.1101/gr.166439.113

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© 2014 Lay et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — Loss of DNA methylation in the neobladder occurs dynamically on non-tissue-specific CpG sites. (A) A heat map showing a subset of probes (n = 748) that is methylated across all normal tissue and exhibits a significant trend of demethylation over time in the neobladder (Benjamini-Hochberg adjusted P-value < 0.05). (B) Nonmetric MDS using demethylated probes shows increased variation between the neobladder samples. (C) Linear regression analysis shows that demethylation in the neobladder is also time dependent and occurs at a rate comparable to de novo methylation in intestine-specific probes. (D) Demethylation of TJP2 is validated using pyrosequencing. T-test was performed. (*) P-value < 0.05.