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. 2014 Apr;24(4):604–615. doi: 10.1101/gr.162172.113

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© 2014 Shao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 4. — Dosage compensation of the Z chromosome in pseudomale testes. (A) Methylated cytosine (mC) density (5-kb window), log2-transformed expression ratios (running averages of 20 genes), and DMR profiles of the Z chromosome. The light gray box indicates the outstanding dosage-compensated region where DMRs were concentrated ([red vertical lines] DMRs that were up-methylated in P-ZWm, [blue vertical lines] DMRs that were up-methylated in ZZm), and the green block indicates the pseudoautosomal region (PAR) where Z and W chromosomes still pair in meiosis. Only 22 genes were annotated in PAR. Z-chromosomal to autosomal gene expression ratios (Z:A) in P-ZWm (B), F1-ZWm (C), and ZZm (D). The dosage compensation region (light gray box in A) is plotted in red. For each Z interval, the expression level of each Z-gene was first divided by the median expression level of all autosomal genes, then the Z:A ratios in each interval were plotted.