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. 2014 Mar 28;8:88. doi: 10.3389/fncel.2014.00088

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Copyright © 2014 Furukawa, Yamada, Akita, Matsushima, Yanagawa and Fukuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GABA_ARs in radially migrating neurons are activated by endogenous taurine. (A) Typical trace of a GABA_AR-mediated tonic current in an RFP-positive cell in the SP under normal conditions. V_H was -60 mV. (B) SR95531-sensitive inward current induced by the application of GES. The baseline currents immediately before (for 5 s) the initiation and the cessation of SR95531 application were averaged, to determine the tonic currents based on their difference. (C) Averaged tonic current amplitudes before and after GES application. There were no significant differences between the GAD67⁺^/⁺ (n = 5) and GAD67^GFP/GFP (n = 5) mice. (D) HPLC measurements of the taurine concentrations in the cortical slice incubation medium either without (Control, n = 5) or with GES (300 μM, n = 4). Error bar: mean ± SEM. *P < 0.01.