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. 2014 Mar 28;8:88. doi: 10.3389/fncel.2014.00088

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Copyright © 2014 Furukawa, Yamada, Akita, Matsushima, Yanagawa and Fukuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of maternal D-CSA administration on ambient taurine levels and GABA_AR-mediated tonic currents in the fetal neocortex. (A) Ambient taurine levels in fetal cortical slices determined via HPLC. E17.5 GAD67⁺^/⁺ fetuses were obtained from pregnant mice injected with either saline (Control, n = 5) or D-CSA (n = 5). (B) Typical traces of GABA_AR-mediated tonic currents recorded in RFP-positive neurons in the SP regions of GAD67^GFP/GFP fetal cortical slices. The fetuces were obtained from saline- (upper trace) and D-CSA-treated (lower trace) pregnant GAD67^+/GFP mice. (C) Averaged tonic current amplitudes in the SP and the CP regions of cortical slices obtained from GAD67⁺^/⁺ (left bar group) and GAD67^GFP/GFP (right bar group) fetuses either without (gray bars) or with (white bars) maternal D-CSA injection. The numbers in parentheses indicate the number of samples. *P < 0.05, **P < 0.01. Error bar: mean ± SEM.