Table 2.

Pharmacokinetic parameters of the two formulations.

Parameter	Formulations
	Injection	Microspheres
t1/2α (h)	0.22 ± 0.1	0.86 ± 0.3 *
t1/2β (h)	4.9 ± 1.3	7.9 ± 3.4 *
Cmax (ng/mL)	1425.6 ± 154.6	1239.5 ± 136.3
AUC0–t (ng·h/mL)	2234.6 ± 234.1	2555.6 ± 309.2
AUC0–∞ (ng·h/mL)	2635.8 ± 253.2	2875.3 ± 339.6
MRT (h)	12.8 ± 4.6	21.6 ± 3.9 *
CL (L/h)	25.8 ± 6.5	16.7 ± 4.2 *

^*p < 0.05: DTX-loaded microspheres vs. DTX injection.