Table 3.
The AUC0–24 h of DTX in plasma and tissues after i.v. administration of injection and microspheres to mice (n = 5).
| Formulation | Heart | Liver | Spleen | Lung | Kidney | Uterus/ovaries | Plasma |
|---|---|---|---|---|---|---|---|
| DTX injection (ng·h/g) | 1332.8 | 2671.6 | 1979.4 | 1772.9 | 6754.8 | 3139.8 | 1494.4 |
| DTX-loaded microspheres (ng·h/g) | 613.1 | 376.3 | 1699.4 | 7720.6 | 651.9 | 776.1 | 698.5 |
| Ratio a | 0.46 | 0.14 * | 0.86 | 4.35 * | 0.10 * | 0.25 * | 0.47 |
a
The ratio was AUC (DTX-loaded microspheres)/AUC (DTX injection);
*
p < 0.01: DTX-loaded microspheres vs. DTX injection.