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. 2014 Mar 3;15(3):3784–3798. doi: 10.3390/ijms15033784

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — Normalization of acetylcholinesterase (AChE) activity in MK801 (dizocilpine) treated rat pups after physostigmine treatment. AChE activity, determined by an enzymatic activity assay revealed a significant increase in AChE activity at 6, 12 and 24 h after MK801 treatment (dark grey bars) whereas a single co-application of physostigmine significantly reduced AChE activity (light grey bars). Bars represent mean + SD, n = 6 per group, ** p < 0.01 compared to vehicle treated pups, ^## p < 0.01 compared to MK801 treated pups, respectively. ctrl: control; PHY: physostigmine.